USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: IDHP_HUMAN USC-OGP 2-DE database:  IDHP_HUMAN IDHP_HUMAN General information about the entry View entry in simple text format Entry name IDHP_HUMAN Primary accession number P48735 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Isocitrate dehydrogenase [NADP], mitochondrial; Short=IDH; EC=1.1.1.42; AltName: Full=ICD-M; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase; Flags: Precursor;. Gene name Name=IDH2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0936: pI=7.82; Mw=43304 Cross-references UniProtKB/Swiss-Prot P48735; IDHP_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IDHP_HUMAN Primary accession number P48735 Secondary accession number(s) B2R6L6 B4DFL2 Q96GT3 Sequence was last modified on  April 3, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 170) Name and origin of the protein Description RecName: Full=Isocitrate dehydrogenase [NADP], mitochondrial; Short=IDH; EC=1.1.1.42; AltName: Full=ICD-M; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase; Flags: Precursor; Gene name Name=IDH2 Encoded on Name=IDH2 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; Mitochondrion; NADP; Oxidoreductase; Reference proteome; Transit peptide; Tricarboxylic acid cycle. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X69433; CAA49208.1; -; mRNA EMBL AK294148; BAG57473.1; -; mRNA EMBL AK312627; BAG35513.1; -; mRNA EMBL AK316388; BAH14759.1; -; mRNA EMBL AC087284; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC092769; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471101; EAX02082.1; -; Genomic_DNA EMBL BC009244; AAH09244.1; -; mRNA EMBL BC071828; AAH71828.1; -; mRNA CCDS CCDS10359.1; -. [P48735-1]; . CCDS CCDS76792.1; -. [P48735-2]; . PIR S57499; S57499; . RefSeq NP_001276839.1; NM_001289910.1. [P48735-2]; . RefSeq NP_001277043.1; NM_001290114.1; . RefSeq NP_002159.2; NM_002168.3. [P48735-1]; . UniGene Hs.596461; -; . PDB 4JA8; X-ray; 1.55 A; A/B=41-452 PDB 5GIS; X-ray; 1.93 A; C=165-180 PDBsum 4JA8; -; . PDBsum 5GIS; -; . ProteinModelPortal P48735; -; . SMR P48735; -; . BioGrid 109644; 19; . DIP DIP-61416N; -; . IntAct P48735; 7; . MINT MINT-3016964; -; . STRING 9606.ENSP00000331897; -; . DrugBank DB01727; Isocitric Acid; . iPTMnet P48735; -; . PhosphoSitePlus P48735; -; . SwissPalm P48735; -; . BioMuta IDH2; -; . DMDM 20141568; -; . OGP P48735; -; . UCD-2DPAGE P48735; -; . EPD P48735; -; . MaxQB P48735; -; . PaxDb P48735; -; . PeptideAtlas P48735; -; . PRIDE P48735; -; . DNASU 3418; -; . Ensembl ENST00000330062; ENSP00000331897; ENSG00000182054. [P48735-1]; . Ensembl ENST00000540499; ENSP00000446147; ENSG00000182054. [P48735-2]; . GeneID 3418; -; . KEGG hsa:3418; -; . UCSC uc002box.4; human. [P48735-1]; . CTD 3418; -; . DisGeNET 3418; -; . GeneCards IDH2; -; . HGNC HGNC:5383; IDH2; . HPA HPA007831; -; . MalaCards IDH2; -; . MIM 137800; phenotype; . MIM 147650; gene; . MIM 613657; phenotype; . neXtProt NX_P48735; -; . OpenTargets ENSG00000182054; -; . Orphanet 251589; Anaplastic astrocytoma; . Orphanet 251663; Anaplastic oligoastrocytoma; . Orphanet 251630; Anaplastic oligodendroglioma; . Orphanet 79315; D-2-hydroxyglutaric aciduria; . Orphanet 296; Enchondromatosis; . Orphanet 251601; Fibrillary astrocytoma; . Orphanet 251604; Gemistocytic astrocytoma; . Orphanet 163634; Maffucci syndrome; . Orphanet 251656; Oligoastrocytoma; . Orphanet 251627; Oligodendroglioma; . Orphanet 251598; Protoplasmic astrocytoma; . PharmGKB PA29631; -; . eggNOG KOG1526; Eukaryota; . eggNOG COG0538; LUCA; . GeneTree ENSGT00390000012547; -; . HOGENOM HOG000019858; -; . HOVERGEN HBG006119; -; . InParanoid P48735; -; . KO K00031; -; . OMA GSGPKEW; -; . OrthoDB EOG091G06IY; -; . PhylomeDB P48735; -; . TreeFam TF300428; -; . BioCyc MetaCyc:HS00021-MONOMER; -; . BRENDA 1.1.1.42; 2681; . Reactome R-HSA-71403; Citric acid cycle (TCA cycle); . SIGNOR P48735; -; . ChiTaRS IDH2; human; . GeneWiki IDH2; -; . GenomeRNAi 3418; -; . PRO PR:P48735; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000182054; -; . CleanEx HS_IDH2; -; . ExpressionAtlas P48735; baseline and differential; . Genevisible P48735; HS; . GO GO:0005829; C:cytosol; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0005777; C:peroxisome; IEA:Ensembl; . GO GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB; . GO GO:0000287; F:magnesium ion binding; ISS:UniProtKB; . GO GO:0051287; F:NAD binding; IEA:InterPro; . GO GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB; . GO GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc; . GO GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW; . GO GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB; . GO GO:0006741; P:NADP biosynthetic process; IEA:Ensembl; . GO GO:1903976; P:negative regulation of glial cell migration; IEA:Ensembl; . GO GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl; . GO GO:1904465; P:negative regulation of matrix metallopeptidase secretion; IEA:Ensembl; . GO GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome; . Gene3D 3.40.718.10; -; 1; . InterPro IPR019818; IsoCit/isopropylmalate_DH_CS; . InterPro IPR004790; Isocitrate_DH_NADP; . InterPro IPR024084; IsoPropMal-DH-like_dom; . PANTHER PTHR11822; PTHR11822; 1; . Pfam PF00180; Iso_dh; 1; . PIRSF PIRSF000108; IDH_NADP; 1; . SMART SM01329; Iso_dh; 1; . TIGRFAMs TIGR00127; nadp_idh_euk; 1; . PROSITE PS00470; IDH_IMDH; 1; .

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